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The sustained BP response in normotensive subjects to ambulatory BP lowering is associated with significant early declines in aortic stiffness and intima media thickness, with favorable coronary plaque regression and alleviation of endothelial dysfunction, and with changes in pulse wave velocity (PWV) and left ventricular mass. ²⁵²²⁵⁸ A meta-analysis of randomized controlled trials of antihypertensive medications demonstrated that when compared with placebo, all BP lowering medications except α-blockers have a similar efficacy to reduce aBP, where a 10 mmHg ⁵⁹ and a 5 mmHg ²³ decrease in office and ambulatory BP, respectively, have been reported.

Elevated office BPs before therapy is initiated and inadequate lowering of elevated BP levels with optimal pharmacological treatment of hypertension are factors that may indicate poor treatment response and adverse clinical outcomes in patients with hypertension. ^{76, 77} Therefore, it is important to know BP levels before starting antihypertensive therapy and during the first months of treatment to identify patients who will have a poor response and have a higher risk of poor cardiovascular outcomes.

Patients with pseudoresistant hypertension have a failure to lower office BP to less than 140/90 mm Hg with treatment of three or more antihypertensive agents of first choice or a fixed-dose combination of two or more of these agents. An elevated office BP that has not been adequately controlled despite treatment with a fixed-dose combination of at least three antihypertensive agents of first choice is defined as nonadherence.

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Your Office 365 subscription includes support in the use and features of products and services that Office 365 administrators sell. For example, they sell security incident responder, enterprise mobility, security, and compliance services. Support for Office365 includes security incident responder (SIR) help desk and community support, and enterprise mobility help desk and community support. For more information, visit the Office 365 app support portal. For services that you resell, you can contact the service provider directly for support. They are also available to provide assistance for any paid features of Office 365.

The new CORE App Connector for Microsoft Power BI offers the ability to make your CORE data available to Power BI. Users can create custom reports, dashboards and visualizations directly in the Power BI application using your raw data, making it easy to assess how your data is impacting business.

In addition to the patches listed above, we also recommend that you install at least the following updates. They are not critical to the running of the product.

• Update to KB4413553, which is a fix for the Office Online Server 2016 CTD when Microsoft Office Professional Plus, Microsoft Office Student Plus, and Microsoft Office Business Essentials are installed on the same computer.
• Update to KB4413352, which is a fix for an issue that prevented some user authentication requests from completing when using Office Online Server and the Add-in for Office client applications.
• Update to KB4413334, which is a fix for an issue that caused the Office Online Server APIs to display incorrect values in the Outlook API output. This issue could cause office.office.protection.find-device-policy to return an incorrect value.
• Update to KB4413563, which is a fix for an issue that could cause the Office Online Server APIs to report incorrect information in the Office API output.
• Update to KB4413513, which is a fix for an issue that could cause the OpenUI command call to fail.
• Update to KB4413496, which is a fix for an issue that caused the Office Online Server APIs to display incorrect values in the Azure AD Subscription API output.
• Update to KB4413485, which is a fix for an issue that could cause the Office Online Server APIs to report incorrect information in the Office API output.

If you are a new Office 365 customer, the trial is reset to the earliest end date and expiration time of your current subscription. Expiration dates are the last day you can start a new subscription. Learn more about subscription expiration.

Use the Microsoft Deployment Tool to configure the settings on the Windows devices you would like to add to the deployment. The Deployment Tool will walk you through the settings required to deploy Office.

Apply the settings from the existing Office deployment to the new installation. If you have not started the deployment yet, the task will start and you will be able to see the deployment settings and work through them.

Accelerators that are not listed in the following table don’t support this combination. You cannot add two accelerators that do not support the same version of Office, but you can add accelerators that do support the same version of Office.

If youre upgrading from a Windows Installer (MSI) version of Office, you can get Click-to-Run versions of the same language resources for example, language packs, language interface packs, or proofing tools installed when you deploy Office LTSC 2021. For more information, see Remove existing MSI versions of Office when upgrading to Microsoft 365 Apps. Even though this article is about Microsoft 365 Apps, most of the information also applies to Office LTSC 2021.

If youre upgrading from a Windows Installer (MSI) version of Office, you can get Click-to-Run versions of the same language resources for example, language packs, language interface packs, or proofing tools installed when you deploy Office LTSC 2021. For more information, see Remove existing MSI versions of Office when upgrading to Microsoft 365 Apps.

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• Windows 7/8.1/10
• SP1+
• Intel(R) i5 or i7, 2.5 GHz
• Windows Server 2012 R2

• Support for iOS10 (iOS 9 and lower required)
• Support for WSUS Offline Update
• New reporting
• Single sign on for Mobile apps
• Option for User Profile Synchronization
• Promote 2-factor authentication from file shares
• Support for Microsoft Exchange Online
• Log in the Outlook Web app with Dropbox, Google, Facebook, Microsoft Live, or Yahoo
• Get notifications for Office 365 service events
• Exchange Online single sign on
• User Profile Service (UPS) Single sign on
• SharingIntent
• Mail Flow
• Outlook.com support (on mobile)
• Cloud-based and offline sync
• Advanced security features
• Session Management
• REST APIs

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